珞珈講壇第308講預(yù)告

時(shí) 間：2019年10月24日（周四）15：30

地 點(diǎn)：武漢大學(xué)生命科學(xué)學(xué)院二樓報(bào)告廳

主講人：季維智 中國(guó)科學(xué)院院士

題 目：逆水行舟，不進(jìn)則退：靈長(zhǎng)類(lèi)生殖與發(fā)育研究

主講人簡(jiǎn)介：

季維智， 1950年生，博士生導(dǎo)師，中國(guó)科學(xué)院院士，昆明理工大學(xué)特聘教授，靈長(zhǎng)類(lèi)轉(zhuǎn)化醫(yī)學(xué)研究院院長(zhǎng)，云南省靈長(zhǎng)類(lèi)生物醫(yī)學(xué)動(dòng)物重點(diǎn)實(shí)驗(yàn)室理事長(zhǎng)，生物醫(yī)學(xué)動(dòng)物模型國(guó)家地方聯(lián)合工程研究中心主任。季維智院士是“世界經(jīng)濟(jì)論壇全球未來(lái)理事會(huì)”理事（2016-2018）、“國(guó)家干細(xì)胞研究指導(dǎo)協(xié)調(diào)委員會(huì)”專(zhuān)家、“國(guó)家重大科學(xué)研究計(jì)劃生殖與發(fā)育專(zhuān)家組”成員(2006-2014)、“國(guó)家實(shí)驗(yàn)動(dòng)物研究委員會(huì)”專(zhuān)家組成員、973項(xiàng)目首席科學(xué)家。

季維智院士長(zhǎng)期堅(jiān)持靈長(zhǎng)類(lèi)研究，圍繞靈長(zhǎng)類(lèi)早期胚胎發(fā)育調(diào)控，干細(xì)胞多能性和人類(lèi)疾病的猴模型及致病機(jī)理等科學(xué)問(wèn)題，形成了從體外受精、胚胎早期發(fā)育、基因編輯以及干細(xì)胞等系統(tǒng)研究體系。在靈長(zhǎng)類(lèi)生殖和發(fā)育的分子機(jī)制，干細(xì)胞的自我更新和分化調(diào)控等方面都有新的發(fā)現(xiàn)，在國(guó)際上首次獲得了猴多能性干細(xì)胞，開(kāi)啟了靶向基因編輯建立靈長(zhǎng)類(lèi)動(dòng)物模型的研發(fā)和應(yīng)用。

季維智院士長(zhǎng)期為國(guó)家生殖發(fā)育、干細(xì)胞專(zhuān)家組服務(wù)，為中國(guó)生殖與干細(xì)胞研究作出了突出貢獻(xiàn)，也為中國(guó)靈長(zhǎng)類(lèi)研究的國(guó)際化并躋身于世界先進(jìn)行列發(fā)揮了重要作用。承擔(dān)多項(xiàng)國(guó)家級(jí)重點(diǎn)研發(fā)項(xiàng)目，包括科技部973計(jì)劃“細(xì)胞多能性和人類(lèi)重大疾病的猴模型研究”、“獼猴干細(xì)胞自我更新、定向分化的分子機(jī)制”、“非人靈長(zhǎng)類(lèi)克隆及治療性克隆的機(jī)理研究”、科技部國(guó)家科技支撐計(jì)劃“人類(lèi)疾病的靈長(zhǎng)類(lèi)動(dòng)物模型開(kāi)發(fā)和標(biāo)準(zhǔn)化研究”及科技部863計(jì)劃“靈長(zhǎng)類(lèi)動(dòng)物模型與安全性評(píng)價(jià)的研究與應(yīng)用”等。在 Cell，Cell Stem Cell，PNAS，JBC，Stem Cell Reports, Biomaterials, Stem Cells，Biol. Reprod.，Hum. Reprod.等雜志以通訊作者或第一作者發(fā)表 SCI 論文 70 余篇。其中，2014 年在 Cell 發(fā)表的基因編輯猴的論文被評(píng)價(jià)為人類(lèi)疾病模型建立的里程碑性工作、入選 2014 年世界十大科技進(jìn)展（MIT）、2014 年 Cell 最佳論文(Cell)、 2014 年世界最成功的 8 大事件之一(Nature)。

Brief Introduction of Professor Weizhi Ji

Prof. Weizhi Ji currently is Member of Chinese Academy of Sciences, Professor and Director of Yunnan Key Laboratory of Primate Biomedical Research/ Institute of Primate Translational Medicine, Kunming University of Science and Technology. In 1985-1987, Prof. Ji worked as a scientist in Oregon National Primate Research Center and Smithsonian Institution in US. Since 1996 till 2005, he had served as the director of Kunming Institute of Zoology, Chinese Academy of Sciences. In the meantime, from 1995 to 1997, he held visiting professor position in University of Wisconsin. In 1996, Prof. Ji was named as the director of China-US Joint Primate Biology Laboratory, which was co-established by Kunming Institute of Zoology and Wisconsin Primate Research Center.

Prof. Ji has been engaged in primate reproductive biology research since 1980s and he takes the lead in primate stem cell research in China. His lab reported the first gene-modified rhesus and cynomolgus monkeys via Cas9/RNA-mediated gene targeting in 2014, first proved the feasibility of generate chimeric monkeys using ESCs in 2015 and revealed global DNA de novo methylation during monkey pre-implantation development. His team has established human, monkey, rabbit and mouse embryonic stem cell lines and adult stem cell lines. His study found the mechanism of embryonic stem cells differentiate into neural stem cells in vivo and the integration mechanisms in vitro. Now his research focuses on generation of transgenic monkeys, primate embryonic development, stem cell self-renewal mechanisms and stem cell replacement therapy research, where he has published a lot of articles in high level magazines of this area, such as Cell, Cell Stem Cells, PNAS, Biology of Reproduction, Human Reproduction and other magazines.